Cocrystals with at least one pharmaceutical component

Pharmaceutical Cocrystals: An Overview

In the last few years, a large number of drugs have been discovered with low aqueous solubility. Among these recently discovered drugs, about 60-70% of the compounds are related to the BCS Class II (low solubility/high permeability) and IV (low solubility/ low permeability)[1,2]. Many active pharmaceutical ingredients (APIs) have not been developed in formulations due to low aqueous solubility,...

Towards more Efficient Screening of Pharmaceutical Cocrystals

Pharmaceutical Cocrystals and Their Physicochemical Properties

This review article will highlight and discuss the advances made over the last 10 years pertaining to physical and chemical property improvements through pharmaceutical cocrystals and, hopefully, draw closer the fields of crystal engineering and pharmaceutical sciences.

Pharmaceutical cocrystals of diflunisal and diclofenac with theophylline.

Pharmaceutical cocrystals of nonsteroidal anti-inflammatory drugs diflunisal (DIF) and diclofenac (DIC) with theophylline (THP) were obtained, and their crystal structures were determined. In both of the crystal structures, molecules form a hydrogen bonded supramolecular unit consisting of a centrosymmetric dimer of THP and two molecules of active pharmaceutical ingredient (API). Crystal lattic...

“At least one” caching

We consider a variant of the caching problem, where each request is a set of pages of a fixed size, instead of a single page. In order to serve such a request, we require at least one of those pages to be present in the cache. Each page is assumed to have unit size and unit cost for getting loaded into the cache. We prove lower bounds on the competitive ratio for this problem in both the determ...